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Bioactive hyaluronic acid fragments inhibit lipopolysaccharide-induced inflammatory responses via the

Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 292-301 doi: 10.1007/s11684-020-0806-5

Abstract: However, the role of LMW-HA in inflammatory response is controversial.aimed to investigate the effect of bioactive hyaluronan (B-HA) on lipopolysaccharide (LPS)-induced inflammatoryThe mRNA expression and the production of inflammatory cytokines were determined using quantitative real-timecytokine IL-10 in LPS-induced inflammatory responses in THP-1-derived macrophages and .B-HA could be a potential anti-inflammatory drug in the treatment of inflammatory disease.

Keywords： bioactive hyaluronan     lipopolysaccharide     inflammatory cytokines     TLR4     human macrophages    

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Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 260-267 doi: 10.15302/J-FASE-2016116

Abstract: The innate immune response is the first line of defense against viral invasion and pro-inflammatory chemokinesand cytokines have a critical function in the innate immune responses against virus infections.The ability of a rabies virus (RABV) to induce the expression of chemokines and cytokines can lead toIn this review, the crucial contribution of chemokines/cytokines to clearing RABV from the CNS is discussedIn addition, recombinant RABV expressing cytokines and chemokines can induce elevated innate and adaptive

Keywords： antiviral     blood brain barrier     chemokines and cytokines     innate immunity     rabies virus    

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Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion

Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 195-203 doi: 10.1007/s11684-012-0189-3

Abstract:

The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofenThe anti-inflammatory effect of SDBT was evaluated using the mouse ear edema test with xylene.SDBT displayed more significant anti-inflammatory effects than CT.The dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea

Keywords： ibuprofen     solid dispersion     physical mixture     dissolution     anti-inflammatory effect    

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Cytokines and inflammation in adipogenesis: an updated review

Ning Jiang, Yao Li, Ting Shu, Jing Wang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 314-329 doi: 10.1007/s11684-018-0625-0

Abstract: The biological relevance of cytokines is known for more than 20 years.Evidence suggests that adipogenesis is one of the biological events involved in the regulation of cytokines, and pro-inflammatory cytokines (e.g., TNF and IL-1 ) inhibit adipogenesis through various pathwaysIntervention studies showed that pro-inflammatory cytokine antagonists improve metabolism in patientsAlthough the interplay of cytokines and lipid metabolism is yet incompletely understood, cytokines represent

Keywords： cytokines     inflammation     adipogenesis     type 2 diabetes mellitus     metabolic disorder    

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Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 139-145 doi: 10.1007/s11684-015-0377-z

Abstract: view is supported by a large body of literature, it has been challenged by growing evidence that pro-inflammatorycytokines may favor insulin sensitivity through induction of energy expenditure.article, interleukin 15 (IL-15) is used as a new example to explain the beneficial effects of the pro-inflammatorycytokines.In summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance

Keywords： inflammation     obesity     cytokine     energy expenditure     insulin resistance    

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The relationship between progesterone and Th-related cytokines in plasma during early pregnancy in cows

Lei CHENG,Youdong XIN,Xiaohua LIU,Xiuzhong HU,Min XIANG,Dingfa WANG,Shuhong ZHAO

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 147-152 doi: 10.15302/J-FASE-2016099

Abstract: pregnancy and successful embryo development is dependent on the maternal immunomodulation of Th-related cytokinesTherefore, we evaluated plasma P4 concentrations and expressions of three Th-related cytokines, interleukinsThe cytokines measured were not affected in either the high-P4 group (>11.1 ng·mL ) or the low-P4 groupA weak negative correlation between IL-1β and IL-6 was observed, but none of the cytokines was associated

Keywords： dairy cow     progesterone     pregnancy     cytokine    

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Advances in immunopathogenesis of adult immune thrombocytopenia

Xinguang Liu, Yu Hou, Jun Peng

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 418-424 doi: 10.1007/s11684-013-0297-8

Abstract:

Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated accelerated platelet destruction and/or suppressed platelet production. Although the development of autoantibodies against platelet glycoproteins remains central in the pathophysiology of ITP, several abnormalities involving the cellular mechanisms of immune modulation have been identified, and the pathways behind the immune-mediated destruction of platelets have opened new avenues for the design of specific immunotherapies in an attempt to reduce the platelet destruction. This review is primarily focused on the recent literature with respect to immunopathological mechanisms in patients with ITP.

Keywords： primary immune thrombocytopenia     B lymphocytes     T lymphocytes     antigen-presenting cells     cytokines    

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Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 909-918 doi: 10.1007/s11684-021-0890-1

Abstract: initial cytokine profiling using plasma samples from 39 patients and 18 healthy donors found a series of cytokinesIn addition, verification in 81 patients with APL demonstrated that the two cytokines were positively

Keywords： acute promyelocytic leukemia     intracranial hemorrhage     cytokines     biomarker    

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Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 319-332 doi: 10.1007/s11684-017-0569-9

Abstract:

Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes mellitus patients and is characterized by thickened glomerular basement membrane, increased extracellular matrix formation, and podocyte loss. These phenomena lead to proteinuria and altered glomerular filtration rate, that is, the rate initially increases but progressively decreases. DN has become the leading cause of end-stage renal disease. Its prevalence shows a rapid growth trend and causes heavy social and economic burden in many countries. However, this disease is multifactorial, and its mechanism is poorly understood due to the complex pathogenesis of DN. In this review, we highlight the new molecular insights about the pathogenesis of DN from the aspects of immune inflammation response, epithelial–mesenchymal transition, apoptosis and mitochondrial damage, epigenetics, and podocyte–endothelial communication. This work offers groundwork for understanding the initiation and progression of DN, as well as provides ideas for developing new prevention and treatment measures.

Keywords： diabetic nephropathy     immune inflammatory response     epithelial–mesenchymal transition     apoptosis     mitochondrial    

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Metformin and metabolic diseases: a focus on hepatic aspects

Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 173-186 doi: 10.1007/s11684-015-0384-0

Abstract:

Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses hepatic glucose production (HGP), serving as the main mechanism by which metformin improves hyperglycemia of T2D. Biochemically, metformin suppresses gluconeogenesis and stimulates glycolysis. Metformin also inhibits glycogenolysis, which is a pathway that critically contributes to elevated HGP. While generating beneficial effects on hyperglycemia, metformin also improves insulin resistance and corrects dyslipidemia in patients with T2D. These beneficial effects of metformin implicate a role for metformin in managing non-alcoholic fatty liver disease. As supported by the results from both human and animal studies, metformin improves hepatic steatosis and suppresses liver inflammation. Mechanistically, the beneficial effects of metformin on hepatic aspects are mediated through both adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. In addition, metformin is generally safe and may also benefit patients with other chronic liver diseases.

Keywords： metformin     diabetes     hepatic steatosis     inflammatory response     insulin resistance    

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Effect of levonorgestrel intrauterine system on IGF-1 and the dependablity study of prevention pelvic inflammatory

Wu Xiaojie,Liu Xia,Tao Yueping,Wang Jie

Strategic Study of CAE 2015, Volume 17, Issue 6,   Pages 4-7

Abstract: insulin-like growth factor-l (IGF-1) and the result of levonorgestrel Intrauterine System Prevention pelvic inflammatoryPatients were followed up for 2Syears to analyse the effluence of pelvic inflammatory disease.Followed up for 2 years, 14 cases has pelvic inflammatory disease in study group,39 cases has pelvicinflammatory disease in control group,there was a significant differences.Conclusions:It may be the mainSmechanism of Prevention pelvic inflammatory disease and inhibition endometrium

Keywords： levonorgestrel     Intrauterine system insulin-like growth factor-1     pelvic inflammatory disease    

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Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Engineering doi: 10.1016/j.eng.2023.06.007

Abstract: Axin1 expression was analyzed in human inflammatory bowel disease datasets.We found increased Axin1 expression in the colonic epithelium of human inflammatory bowel disease (IBDmechanistic studies using specific Axin1 mutations elucidating how Axin1 modulates the microbiome and host inflammatory

Keywords： Axin1     Bacteria     Microbiome inflammation     Inflammatory bowel disease     Immunity     Microbiome     Paneth cells     Akkermansia    

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Recent advances in myeloid-derived suppressor cell biology

Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 232-251 doi: 10.1007/s11684-020-0797-2

Abstract: In recent years, studying the role of myeloid-derived suppressor cells (MDSCs) in many pathological inflammatory

Keywords： non-human primates (rhesus macaques)     myeloid-derived pro-inflammatory cells (MDPCs)     autoimmune disorders    

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Effect of IL-10 on formation of foam cell induced by ox-LDL

WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 298-302 doi: 10.1007/s11684-008-0057-3

Abstract: IL-10, an anti-inflammatory cytokine, can inhibit the effect of ox-LDL and LPS.These results indicate that inflammatory effects in blood vessels can speed up foam cell formation.

Keywords： inflammatory     presence     interleukin-10     dose-dependent     ox-LDL    

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Current State of Monoclonal Antibody Therapy for Allergic Diseases Review

Yan Chen, Wei Wang, Huihui Yuan, Yan Li, Zhe Lv, Ye Cui, Jie Liu, Sun Ying

Engineering 2021, Volume 7, Issue 11,   Pages 1552-1556 doi: 10.1016/j.eng.2020.06.029

Abstract: can promote or trigger T helper 2 (Th2)-type immune responses, leading to production of the type 2 cytokines(IL-33) have been also described and proposed to develop monoclonal antibodies against either these cytokinesThe present review aims to briefly outline the role of monoclonal antibodies targeting the cytokines

Keywords： Allergic disease     Monoclonal antibody     Anti-IgE     Cytokines     Clinical trials    

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Title Author Date Type Operation

Bioactive hyaluronic acid fragments inhibit lipopolysaccharide-induced inflammatory responses via the

Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang

Journal Article

Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Journal Article

Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion

Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen

Journal Article

Cytokines and inflammation in adipogenesis: an updated review

Ning Jiang, Yao Li, Ting Shu, Jing Wang

Journal Article

Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Journal Article

The relationship between progesterone and Th-related cytokines in plasma during early pregnancy in cows

Lei CHENG,Youdong XIN,Xiaohua LIU,Xiuzhong HU,Min XIANG,Dingfa WANG,Shuhong ZHAO

Journal Article

Advances in immunopathogenesis of adult immune thrombocytopenia

Xinguang Liu, Yu Hou, Jun Peng

Journal Article

Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic leukemia

Journal Article

Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Journal Article

Metformin and metabolic diseases: a focus on hepatic aspects

Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu

Journal Article

Effect of levonorgestrel intrauterine system on IGF-1 and the dependablity study of prevention pelvic inflammatory

Wu Xiaojie,Liu Xia,Tao Yueping,Wang Jie

Journal Article

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Journal Article

Recent advances in myeloid-derived suppressor cell biology

Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud

Journal Article

Effect of IL-10 on formation of foam cell induced by ox-LDL

WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng

Journal Article

Current State of Monoclonal Antibody Therapy for Allergic Diseases

Yan Chen, Wei Wang, Huihui Yuan, Yan Li, Zhe Lv, Ye Cui, Jie Liu, Sun Ying

Journal Article